TY - JOUR
T1 - Oral exposure to arsenic causes hearing loss in young people aged 12-29 years and in young mice
AU - Li, Xiang
AU - Ohgami, Nobutaka
AU - Omata, Yasuhiro
AU - Yajima, Ichiro
AU - Iida, Machiko
AU - Oshino, Reina
AU - Ohnuma, Shoko
AU - Ahsan, Nazmul
AU - Akhand, Anwarul Azim
AU - Kato, Masashi
N1 - Funding Information:
This study was supported in part by Grants-in-Aid for Scientific Research on Innovative Areas (24108001, 16H01639), Scientific Research (A) (15H01743 and 15H02588), (B) (16H02962) and (C) (25460178, 16K08343 and 16K11177) and Grant-in-Aid for Challenging Exploratory Research (26670525) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), the Japan Health Foundation, the Mitsui & Co., Ltd. Environment Fund, Foundation from Center for Advanced Medical and Clinical Research Nagoya University Hospital, the Mitsubishi Foundation, the Research Foundation for Health Sciences (The KENKOKAGAKU Zaidan), Aichi Health Promotion Foundation, Nagono Medical Foundation, The Salt Science Research Foundation and AEON Environmental Foundation and Sumitomo Foundation (1631119). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2017 The Author(s).
PY - 2017/12/1
Y1 - 2017/12/1
N2 - There is no information on the association between oral exposure to arsenic (As) and hearing loss in humans or mice. In this combined epidemiological study and experimental study, the association of oral exposure to As with hearing loss in people aged 12-29 years and young mice was examined. Subjects in the exposure group (n = 48), who were drinking tube well water contaminated with As, showed significantly higher risks of hearing loss at 4 kHz [odds ratio (OR) = 7.60; 95% confidence interval (CI): 1.56, 57.88], 8 kHz (OR = 5.00; 95% CI: 1.48, 18.90) and 12 kHz (OR = 8.72; 95% CI: 2.09, 47.77) than did subjects in the control group (n = 29). We next performed an experiment in which young mice were exposed to As via drinking water at 22.5 mg/L, which is a much greater concentration than that in human studies. The exposure group showed hearing loss and accumulation of As in inner ears. Ex vivo exposure of the organ of Corti from mice exposed to As significantly decreased the number of auditory neurons and fibers. Thus, our combined study showed that oral exposure to As caused hearing loss in young people and young mice.
AB - There is no information on the association between oral exposure to arsenic (As) and hearing loss in humans or mice. In this combined epidemiological study and experimental study, the association of oral exposure to As with hearing loss in people aged 12-29 years and young mice was examined. Subjects in the exposure group (n = 48), who were drinking tube well water contaminated with As, showed significantly higher risks of hearing loss at 4 kHz [odds ratio (OR) = 7.60; 95% confidence interval (CI): 1.56, 57.88], 8 kHz (OR = 5.00; 95% CI: 1.48, 18.90) and 12 kHz (OR = 8.72; 95% CI: 2.09, 47.77) than did subjects in the control group (n = 29). We next performed an experiment in which young mice were exposed to As via drinking water at 22.5 mg/L, which is a much greater concentration than that in human studies. The exposure group showed hearing loss and accumulation of As in inner ears. Ex vivo exposure of the organ of Corti from mice exposed to As significantly decreased the number of auditory neurons and fibers. Thus, our combined study showed that oral exposure to As caused hearing loss in young people and young mice.
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U2 - 10.1038/s41598-017-06096-0
DO - 10.1038/s41598-017-06096-0
M3 - Article
C2 - 28754998
AN - SCOPUS:85026419404
SN - 2045-2322
VL - 7
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 6844
ER -