TY - JOUR
T1 - Photoacoustic mammography capable of simultaneously acquiring photoacoustic and ultrasound images
AU - Asao, Yasufumi
AU - Hashizume, Yohei
AU - Suita, Takahiro
AU - Nagae, Ken Ichi
AU - Fukutani, Kazuhiko
AU - Sudo, Yoshiaki
AU - Matsushita, Toshikazu
AU - Kobayashi, Shuichi
AU - Tokiwa, Mariko
AU - Yamaga, Iku
AU - Fakhrejahani, Elham
AU - Torii, Masae
AU - Kawashima, Masahiro
AU - Takada, Masahiro
AU - Kanao, Shotaro
AU - Kataoka, Masako
AU - Shiina, Tsuyoshi
AU - Toi, Masakazu
N1 - Funding Information:
This work was partially supported by the Innovative Techno-Hub for Integrated Medical Bioimaging Project of the Special Coordination Funds for Promoting Science and Technology, from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.
Publisher Copyright:
© 2016 The Authors.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - We have constructed a prototype photoacoustic mammography system (PAM-02) capable of simultaneously acquiring photoacoustic (PA) and ultrasound (US) images. Each PA, US, and fused PA/US image can be acquired over a wide area of the breast using the scanning module of a US transducer, a PA detector, and optical prisms. The resolution of the PA images exhibits improvement from 2 to 1 mm compared to images acquired using our previous prototype. The maximum scan area of PAM-02 is 90 mm along the horizontal axis and 150 mm along the vertical axis. In a phantom experiment, the available depth was at least 45 mm. A representative example of the application of the PAM-02 prototype in clinical research at Kyoto University is presented and shows S-factor images, which are considered an approximation parameter related to hemoglobin saturation of tumor-related blood vessels. We confirmed the applicability of the system for anatomical and biological research.
AB - We have constructed a prototype photoacoustic mammography system (PAM-02) capable of simultaneously acquiring photoacoustic (PA) and ultrasound (US) images. Each PA, US, and fused PA/US image can be acquired over a wide area of the breast using the scanning module of a US transducer, a PA detector, and optical prisms. The resolution of the PA images exhibits improvement from 2 to 1 mm compared to images acquired using our previous prototype. The maximum scan area of PAM-02 is 90 mm along the horizontal axis and 150 mm along the vertical axis. In a phantom experiment, the available depth was at least 45 mm. A representative example of the application of the PAM-02 prototype in clinical research at Kyoto University is presented and shows S-factor images, which are considered an approximation parameter related to hemoglobin saturation of tumor-related blood vessels. We confirmed the applicability of the system for anatomical and biological research.
KW - mammography
KW - optoacoustic
KW - photoacoustic imaging
KW - ultrasound
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U2 - 10.1117/1.JBO.21.11.116009
DO - 10.1117/1.JBO.21.11.116009
M3 - Article
C2 - 27893089
AN - SCOPUS:84999025247
SN - 1083-3668
VL - 21
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 11
M1 - 116009
ER -