Structure-activity relationship of novel menaquinone-4 analogues: Modification of the side chain affects their biological activities

Yoshitomo Suhara; Norika Hanada; Takashi Okitsu; Miho Sakai; Masato Watanabe; Kimie Nakagawa; Akimori Wada; Kazuyoshi Takeda; Kazuhiko Takahashi; Hiroaki Tokiwa; Toshio Okano

doi:10.1021/jm2013166

Structure-activity relationship of novel menaquinone-4 analogues: Modification of the side chain affects their biological activities

Yoshitomo Suhara, Norika Hanada, Takashi Okitsu, Miho Sakai, Masato Watanabe, Kimie Nakagawa, Akimori Wada, Kazuyoshi Takeda, Kazuhiko Takahashi, Hiroaki Tokiwa, Toshio Okano

研究成果: Article › 査読

12 被引用数 (Scopus)

抄録

We synthesized new vitamin K analogues with demethylation or reduction of the double bonds of the side chain of menaquinone-4 (MK-4) and evaluated their SXR-mediated transcriptional activity as well as the extent of their conversion to MK-4. The results indicated that the analogue with the methyl group deleted at the 7′ site of the side chain part affected conversion activity to MK-4. In contrast, a decrease in the number of the double bonds in the side chain moiety appeared to decrease the SXR-mediated transcriptional activity.

本文言語	English
ページ（範囲）	1553-1558
ページ数	6
ジャーナル	Journal of Medicinal Chemistry
巻	55
号	4
DOI	https://doi.org/10.1021/jm2013166
出版ステータス	Published - 2012 2月 23
外部発表	はい

ASJC Scopus subject areas

分子医療
創薬

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10.1021/jm2013166

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引用スタイル

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AU - Suhara, Yoshitomo

AU - Hanada, Norika

AU - Okitsu, Takashi

AU - Sakai, Miho

AU - Watanabe, Masato

AU - Nakagawa, Kimie

AU - Wada, Akimori

AU - Takeda, Kazuyoshi

AU - Takahashi, Kazuhiko

AU - Tokiwa, Hiroaki

AU - Okano, Toshio

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