Studies on Organic Fluorine Compounds. XLV. Synthesis and Regioselective Substitution Reaction of 3-Trifluoromethylfuran

KOSUKE KAWADA, Osamu Kitagawa, YOSHIRO KOBAYASHI

研究成果: Article査読

抄録

3-Trifluoromethylfuran (1) was efficiently synthesized by the reaction of 4-methyloxazole with 3, 3, 3-trifluoropropyne. Lithiation of 1 with n-butyllithium followed by reaction with an electrophile gave the corresponding 2-substituted 3-trifluoromethylfuran (4). Starting from 2-triethylsilyl-3-trifluoromethylfuran (4a), 2-substituted 4-trifluoromethylfurans (6) were synthesized.
本文言語English
ページ(範囲)3670-3674
ジャーナルChemical and Pharmaceutical Bulletin
33
9
出版ステータスPublished - 1985

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