@article{60722fa48e834ca1ae5003117c01b7db,
title = "Study on structure–activity relationship of vitamin K derivatives: Conversion of the naphthoquinone part into another aromatic ring and evaluation of their neuronal differentiation-inducing activity",
abstract = "We synthesized novel vitamin K derivatives by converting the naphthoquinone group to benzene derivatives and benzoquinone. We evaluated their neuronal differentiation activities to investigate the effect of the quinone moiety on this process. We observed that the 1,4-quinone as well as the side chain part play important roles in neuronal differentiation. We also performed QSAR analysis to predict the compounds which would have higher differentiation activity.",
keywords = "Neural differentiation, Neuron, Structure-activity relationship, Vitamin K",
author = "Hiroshi Yoshimura and Yoshihisa Hirota and Seiya Soda and Mayu Okazeri and Yuta Takagi and Atsuko Takeuchi and Chisato Tode and Maya Kamao and Naomi Osakabe and Yoshitomo Suhara",
note = "Funding Information: We are grateful to Takahashi Industrial and Economic Research Foundation, Japan (Y.S.), The Mishima Kaiun Memorial Foundation, Japan (Y.H.), and The Suzuken Memorial Foundation, Japan (Y.H.). This study were partly supported by a Grant-in-aid for Scientific Research (C) [grant numbers 16K08325 : Y.S. 17K00900 : M.K. and 18K11056: Y.H.] from the Japan Society for the Promotion of Science (JSPS) and a Fund for the Promotion of Joint International Research (Fostering Joint International Research (A)) [grant number 18KK0455: Y.H.] from the JSPS. Funding Information: We are grateful to Takahashi Industrial and Economic Research Foundation , Japan (Y.S.), The Mishima Kaiun Memorial Foundation , Japan (Y.H.), and The Suzuken Memorial Foundation , Japan (Y.H.). This study were partly supported by a Grant-in-aid for Scientific Research (C) [grant numbers 16 K08325 : Y.S., 17 K00900 : M.K., and 18 K11056 : Y.H.] from the Japan Society for the Promotion of Science (JSPS) and a Fund for the Promotion of Joint International Research (Fostering Joint International Research (A)) [grant number 18KK0455 : Y.H.] from the JSPS . Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = apr,
day = "15",
doi = "10.1016/j.bmcl.2020.127059",
language = "English",
volume = "30",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "8",
}