抄録
A probe DNA monolayer modified with Au nano-particles was prepared on an Au thin film and used for DNA hybridization detection by surface plasmon resonance (SPR) spectroscopy. This Au particle modified probe DNA monolayer resulted in about a 3.5 times larger SPR angle shift according to the hybridization reaction, compared to that found in a non-modified probe DNA monolayer. By comparison of the SPR image of the particle modified and non-modified probe DNA monolayer, this modification method was shown to be useful in improving the SPR signal for the detection of the unlabelled DNA molecules.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 247-251 |
| ページ数 | 5 |
| ジャーナル | Proceedings of SPIE - The International Society for Optical Engineering |
| 巻 | 4626 |
| DOI | |
| 出版ステータス | Published - 2002 |
| 外部発表 | はい |
| イベント | Biomedical Nanotechnology Architectures and Applications - San Jose, CA, United States 継続期間: 2002 1月 20 → 2002 1月 24 |
ASJC Scopus subject areas
- 電子材料、光学材料、および磁性材料
- 凝縮系物理学
- コンピュータ サイエンスの応用
- 応用数学
- 電子工学および電気工学