Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells

Kimito Kimura; Yoshihisa Hirota; Shigefumi Kuwahara; Atsuko Takeuchi; Chisato Tode; Akimori Wada; Naomi Osakabe; Yoshitomo Suhara

doi:10.1021/acs.jmedchem.6b01717

Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells

Kimito Kimura, Yoshihisa Hirota, Shigefumi Kuwahara, Atsuko Takeuchi, Chisato Tode, Akimori Wada, Naomi Osakabe, Yoshitomo Suhara

研究成果: Article › 査読

14 被引用数 (Scopus)

抄録

We synthesized novel vitamin K₂ analogues that incorporated a heteroatom and an aromatic ring in the side chain and evaluated their effect on the selective differentiation of neuronal progenitor cells into neurons in vitro. The results showed that a menaquinone-2 analogue bearing a p-fluoroaniline had the most potent activity, which was more than twice as great as the control. In addition, the neuronal selectivity was more than 3 times greater than the control.

本文言語	English
ページ（範囲）	2591-2596
ページ数	6
ジャーナル	Journal of Medicinal Chemistry
巻	60
号	6
DOI	https://doi.org/10.1021/acs.jmedchem.6b01717
出版ステータス	Published - 2017 3月 23

ASJC Scopus subject areas

分子医療
創薬

文献へのアクセス

10.1021/acs.jmedchem.6b01717

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フィンガープリント

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引用スタイル

Kimura, K., Hirota, Y., Kuwahara, S., Takeuchi, A., Tode, C., Wada, A., Osakabe, N., & Suhara, Y. (2017). Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells. Journal of Medicinal Chemistry, 60(6), 2591-2596. https://doi.org/10.1021/acs.jmedchem.6b01717

Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells. / Kimura, Kimito; Hirota, Yoshihisa; Kuwahara, Shigefumi その他.
In: Journal of Medicinal Chemistry, Vol. 60, No. 6, 23.03.2017, p. 2591-2596.

研究成果: Article › 査読

Kimura, K, Hirota, Y, Kuwahara, S, Takeuchi, A, Tode, C, Wada, A, Osakabe, N & Suhara, Y 2017, 'Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells', Journal of Medicinal Chemistry, vol. 60, no. 6, pp. 2591-2596. https://doi.org/10.1021/acs.jmedchem.6b01717

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abstract = "We synthesized novel vitamin K2 analogues that incorporated a heteroatom and an aromatic ring in the side chain and evaluated their effect on the selective differentiation of neuronal progenitor cells into neurons in vitro. The results showed that a menaquinone-2 analogue bearing a p-fluoroaniline had the most potent activity, which was more than twice as great as the control. In addition, the neuronal selectivity was more than 3 times greater than the control.",

author = "Kimito Kimura and Yoshihisa Hirota and Shigefumi Kuwahara and Atsuko Takeuchi and Chisato Tode and Akimori Wada and Naomi Osakabe and Yoshitomo Suhara",

note = "Funding Information: Y.S. acknowledges The Naito Foundation. This study was supported in part by a Grant-in-Aid for Scientific Research KAKENHI (Grant 16K08325 to Y.S.) from the Japan Society for Promotion of Science. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

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AU - Takeuchi, Atsuko

AU - Tode, Chisato

AU - Wada, Akimori

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AU - Suhara, Yoshitomo

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